Search results for "intellidrug device"

showing 2 items of 2 documents

Current status in buccal drug delivery

2008

This article overviews the progress made in buccal drug delivery research during the last five years and reports a new high-tech approach to achieve controlled delivery.

Drug permeationSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoBuccal drug deliverySettore MED/50 - Scienze Tecniche Mediche ApplicateIntelliDrug deviceBuccal drug delivery; Drug permeation; Promoting buccal absorption; IntelliDrug devicePromoting buccal absorption
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Potential transbuccal delivery of l-DOPA methylester prodrug: stability in the environment of the oral cavity and ability to cross the mucosal tissue

2016

Levodopa (l-DOPA) is the most effective pharmacologic agent in Parkinson's disease and remains the "gold standard". Nevertheless, in long-term treatments, dyskinesias and motor complications can emerge. In this work, the combined use of l-DOPA methylester hydrochloride prodrug (LDME) with transbuccal drug delivery was supposed as a good alternative method to optimize the bioavailability of l-DOPA, to maintain constant plasma levels and to decrease the drug unwanted effects. The effects of environmental pH on buccal delivery of LDME were evaluated ex vivo. The increase of pH value from 5.8 to 6.2 implies an improvement of drug permeation. Since the pH increase causes the raising of hydrolyti…

DrugHydrochloridemedia_common.quotation_subjectPharmaceutical Science02 engineering and technologyPharmacologyAntiparkinson AgentsLevodopachemical stability03 medical and health scienceschemistry.chemical_compoundDrug Delivery Systems0302 clinical medicineDrug StabilitySettore MED/28 - Malattie OdontostomatologicheProdrugsmedia_commonBuccal permeationMouthintellidrug deviceMouth MucosaParkinson DiseaseGeneral MedicineBuccal administrationPermeationProdrug021001 nanoscience & nanotechnologytransmucosal drug deliveryBioavailabilitychemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliveryprodrug0210 nano-technology030217 neurology & neurosurgeryEx vivo
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